Early studies showed that people who ate lots of fruits and vegetables – foods rich in antioxidants – were less likely to develop such diseases than those who chose other foods. Next, people already taking antioxidant pills were compared to others who weren't taking such supplements. Again, the antioxidants seemed to be protective. But were they really? Taking a closer look at these studies, it's possible that people who choose to eat lots of fruits and vegetables or take supplements may be more health-conscious than those who don't; this may explain these impressive results. Also, fruits and vegetables offer many more nutrients than the few antioxidants we know about.

The best studies are "clinical trials," where a large group of people are randomly assigned either antioxidants or a placebo (a sugar pill). That way, the only difference between the two groups is whether they're getting the antioxidant or not – participants (and usually researchers as well) don't know which group they're in. As it turns out, the latest clinical trials on vitamins C and E and beta-carotene supplements didn't find that they protected against heart disease and cancer. In several studies, smokers in the group taking beta-carotene pills had a higher risk of lung cancer than smokers taking a placebo. Researchers pooled the results of the best-quality studies to examine the effects of antioxidant supplements on the risk of death and showed that they did not prevent death in healthy people or in people with diseases.

Other studies have investigated antioxidants like coenzyme Q10 for Parkinson's disease or traditional antioxidants for the treatment of arthritis but have yet to find any evidence to support antioxidants for treating these conditions. However, there's still so much research going on to settle this question. Meanwhile, that old cliché was right – eat your fruits and veggies, because they're good for you!

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